KMID : 0384320030240090775
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Korean Journal of Family Medicine 2003 Volume.24 No. 9 p.775 ~ p.780
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Prenatal Down Syndrome Screening
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Oh Min-Jeong
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Abstract
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Down syndrome is known as one of the most common causes of mental retardation. Screening for Down¡¯s syndrome in the second trimester of pregnancy, based on the concentrations of various markers in serum and maternal age, has become widely used in the past decade. Down¡¯s syndrome is associated with low maternal serum alpha-fetoprotein and unconjugated estriol concentrations and high maternal serum human chorionic gonadotropin and inhibin A concentrations. Measurements of the first three markers, in addition to age, constitute the widely used triple test; measurements of all four markers with age make up the quadruple test. The triple test shows 62% of detection rate and the quadruple test was substantially better than the triple test (70%). Also several sonographic markers, especially nuchal translucency and nasal bone apprears to be a highly effective method to screen for Down syndrome.
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